The Zhuyuangou Mo deposit is a middle-sized Mo deposit newly discovered in the East Qingling-Dabie Mo metalogenic belt. It is a porphyry Mo deposit.Based on an analytic study of the results obtained from the regional geophysical and geochemical exploration,and geochemical exploration of the ore block in the Zhuyuangou Mo-deposit,the authors summarized the geophysical and geochemical prospecting methods for Mo deposits.The results show that geophysical and geochemical methods have played a significant role in prospecting and exploration and, on such a basis, the authors pointed out some areas which deserve attention in prospecting: the distribution of molybdenum-bearing intrusive bodies in the range of low gravity anomaly and low magnetic anomaly;stacking areas of 1:50 000 high temperature hydrothermal mineral placer anomalies and comprehensive geochemical anomalies of stream sediments of elements like Mo, Pb, (Au) ;overlapping areas of different-scale Mo, Pb, (Ag) geochemical anomalies.