Abstract: Through geological interpretation and alteration anomaly information extraction with remote sensing, rapid pre-selection of large ore concentration areas and delineation of potential mineralization areas can be carried out. In this paper, with the Hongshui River region of the East Kunlun metallogenic belt as a case study, by using WorldView-2 remote sensing images as major data source and adopting methods of image rectification, false color composition, image enhancement, data fusion, alteration anomaly information extraction, field validation, chemical analysis and geological integrated analysis, the authors predicted the potential regions of mineral resources. The results show that the remote sensing technology using high resolution satellite images can be used as an effective method for detection of potential mineral resources enrichment region, which can meet the requirements of mineral resources exploration and assessment in the arid and semi-arid regions in West China and provide the basic data and reference for the deployment of mineral resources exploration.