This paper describes the application of RS and GIS to the comprehensive evaluation in pipe-route selection between Jingbian and Zhengzhou, the most difficult section in the project of transmitting gases from western China to eastern China. Considering the characteristics of this area, the authors established a comprehensive evaluation system of the pipe route with RS as the basic information source. The system includes twelve data layers such as pipe length, traffic conditions, crossed barrier and terrain. Taking GIS as the technological support, the authors carried out spatial analysis and statistical analysis for each topic. By means of Analytic Hierarchy Process (AHP) combined with experts' knowledge, administrative level analysis was used for all element weight defining and sequence arrangement. All routes were objectively evaluated in detail. The best route has been selected, which provides the decision basis for route-selection.