To investigate the REE mine site exploitation in some places, the authors made remote sensing change detection by using Landsat ETM+ (1999) and SPOT (2005) dataset. Based on the results of unsupervised classification, this paper used the “post-classification comparison” change detection technique to analyze the change details, and formulated an accurate “From-to” change matrix. The increased parts of mine sites class were detected, which resulted from the decrease of other classes. Then the distribution of the change parts was delineated on the map. Before change detection, a radiometric normalization method, i.e.,“Scattergram-Controlled Regression”, was introduced to correct the spectral difference of the two temporal datasets. The accuracy assessment was also used to guarantee the acceptability of the classification results. All of these procedures could enhance the accuracy of the final results and lead to satisfactory result.