With the uranium exploration as an example, this paper puts forward a new concept of post-remote sensing application technology based on the thinking of the comprehensive research and deepened application of remote sensing information. This new concept is considered to be an important way to promote the application of remote sensing information from technology to science. On such a basis, the viewpoint of fault-uplift mineralization of sandstone-type uranium is proposed and a model of regional prospecting for uranium in the craton and activated basin of China is established. Under the guidance of the viewpoint and the model and by using the new technique, 3 uranium mineralization belts were found in the Kalpin fault-uplift on the northern margin of Tarim basin, thus achieving good prospecting result.