On the base of the plate tectonic theory, the middle-lower reach of Yeerqianghe River is prospect area for gold, copper and polymetallic mineralization. Because landform is very complex and transportation condition is seriously bad in this area, the study of exploration geology had not been carried out in detail. For this reason, we have analyzed mineralization condition on the base of TM image feature, extracted a lot of useful information which related to mineralization through processing for Landsat TM data and predicted gold, copper and polymetallic mineralization belt.