Abstract: As an important indicator reflecting the geological sensitivity of slopes, relief amplitude is significant for assessing hidden risks of glacial lake outburst floods. This study obtained information on the current status of glacial lakes in the glacial lake concentrated area in the eastern Shishapangma, southern Tibet through interpretation of the GF-2 and ASTER GDEM V3 data on a scale of 1：50 000. The feature extraction of relief amplitude was conducted using the mean change point method. Then, this study conducted a correlation analysis, achieving the hidden risk rating of glacial lake outburst floods. The results are as follows: ① On a scale of 1：50 000, the optimal sampling unit of relief amplitude is 21x21 (0.39 km2). ② The relief amplitude characteristics of glacial lakes include the single, combined, and cross-level types, of the which the risk grade increases successively. ③ Among 1 020 glacial lakes in the study area, the number of glacial lakes with low-, medium-, and high-grade hidden risks of outburst floods accounts for 97.35%, 1.77%, and 0.88%, respectively. This study revealed the practical significance of relief amplitude as an assessment index for the hidden risks of glacial lake outburst floods. Furthermore, this study can provide theoretical references for related studies of similar areas.