Based on 3S technique, surveying and statistic analysis, this paper takes the landscape pattern change in Shenzhen city as a case study. Shenzhen is a rapid urbanization zone in China as well as a constructed city with holistic planning. In this paper, the relationship between the process of a typical rapid urbanization and the landscape spatial pattern was studied. The landscape and class-level pattern indices in the whole Shenzhen city were comparatively studied. The results show that the landscape structure complexity and the fragmentation in Shenzhen have gradually changed from the center to the fringe. The intensity and the development tendency of the gradient zone were also analyzed. The results show that the diversity indexes increased firstly and decreased lastly according to the pattern grads: the index was lower in the city center but higher in the connective area between the city and the country; patch density index and edge density index were also lower in the city center than those in the connective area; the closer the connective area, the higher the heterogeneity. Shape index and fractal dimension also indicate that human disturbance has become stronger from the city to the country. In conclusion, the landscape structure and distribution are evidently associated with human activities.