Based on lots of image processing tests and field inspection, the authors employed Crosta technique and the Principal Component Analysis using TM1~7 (without TM6) to perform alteration mineral mapping in eastern Junggar, Xinjiang. Relevant images, e.g., hydroxyl layer from TM1, 4, 5 and 7 or iron oxide layer from TM1, 3, 4 and 5, were classified by four thresholds, i.e., ＜μ+1.64σ, μ+1.64σ~μ+2σ, μ+2σ~μ+3σ and ＞μ+3σ. The last three groups, treated as remote sensing anomalies and assigned to different colors, were used to overlie the false color composites that were combined with geochemical surveying data (at the scale of 1︰200,000 or 50,000) in grid form through data fusion. The ore prospecting work in eastern Junggar was shed light on by synthetic analyses based on the multi-information images and field work. The ore exploration targets delineated by this study include Xiaosaerbulake and Kekeyuyi in Qinghe County, Beitashan pasture and Wulunbulage in Qitai County, and Dahongshan and Caohugou in Balikun County.