Urbanization is the main factor responsible for the driving force of  NDVI  change. Based on the atmospheric correction by means of the “6S” model，the authors obtained the NDVI data and land use maps from TM imagery. These data were used to study the correlative relationship between NDVI change and land use in Guangzhou City as well as relevant problems. The results show that the vegetation coverage in Guangzhou decreased continuously from 1990 to 2000 but began to increase slowly afterwards. The decrease rates were different in space and were consistent with the city development pattern. The land use degree and city expansion indexes remained increasing after 2000. The model of quantitative relationship with a high adjusted R2 of 0.88 was simulated by using associative analysis，and the result shows that the vegetation decrease is highly related to the activities of human beings in Guangzhou City. Much research work remains to be done in future.